Decreased blood-brain barrier P-glycoprotein function with aging
نویسندگان
چکیده
A48 Decreased blood-brain barrier P-glycoprotein function with aging Martin Bauer, Rudolf Karch, Aiman Abrahim, Claudia C Wagner, Kurt Kletter, Markus Müller and Oliver Langer Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria Department of Medical Computer Sciences, Medical University of Vienna, 1090 Vienna, Austria Department of Radiopharmaceuticals, Austrian Research Centers GmbH – ARC, 2444 Seibersdorf, Austria Department of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, Austria E-Mail: [email protected]
منابع مشابه
Structural and functional characterization of age-associated changes at the blood-brain barrier. A comparative in vivo study in young adult and middle aged Wistar rats
Decreased beta-amyloid clearance in Alzheimer's disease and increased blood-brain barrier permeability in aged subjects have been reported in several articles. However, morphological and functional characterization of blood-brain barrier and its membrane transporter activity have not been described in physiological aging yet. The aim of our study was to explore the structural changes in the bra...
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